Entity Details

Primary name CASP2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP29594
EntryNameCASP2_MOUSE
FullNameCaspase-2
TaxID10090
Evidenceevidence at protein level
Length452
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCasp2

GO terms

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GOName
GO:0001554 luteolysis
GO:0003407 neural retina development
GO:0004197 cysteine-type endopeptidase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420 brain development
GO:0007568 aging
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016020 membrane
GO:0016485 protein processing
GO:0019904 protein domain specific binding
GO:0035234 ectopic germ cell programmed cell death
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site
IPR035702 Caspase-2FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CASP2_MOUSECASP2_MOUSEBioGRID12477715 details
CASP2_MOUSECRADD_MOUSEBioGRID11978827 details