Entity Details

Primary name ARF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N726
EntryNameARF_HUMAN
FullNameTumor suppressor ARF
TaxID9606
Evidenceevidence at protein level
Length132
SequenceStatuscomplete
DateCreated2005-10-11
DateModified2021-06-02

Ontological Relatives

GenesCDKN2A

GO terms

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GOName
GO:0000422 autophagy of mitochondrion
GO:0005759 mitochondrial matrix
GO:0006469 negative regulation of protein kinase activity
GO:0008134 transcription factor binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0030889 negative regulation of B cell proliferation
GO:0033235 positive regulation of protein sumoylation
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046825 regulation of protein export from nucleus
GO:0055105 ubiquitin-protein transferase inhibitor activity
GO:1903214 regulation of protein targeting to mitochondrion
GO:1990000 amyloid fibril formation
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0005654 nucleoplasm
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051882 mitochondrial depolarization
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097718 disordered domain specific binding
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000435 negative regulation of protein neddylation
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0019789 SUMO transferase activity
GO:0032991 protein-containing complex
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0097371 MDM2/MDM4 family protein binding
GO:1900182 positive regulation of protein localization to nucleus
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1990948 ubiquitin ligase inhibitor activity
GO:0000209 protein polyubiquitination
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0008637 apoptotic mitochondrial changes
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048103 somatic stem cell division
GO:0050821 protein stabilization
GO:0070534 protein K63-linked ubiquitination
GO:0090398 cellular senescence
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR010868 Tumor suppressor ARFFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ARF_HUMANBCL6_MOUSEBioGRID15567177 details