Entity Details

Primary name CDK4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP30285
EntryNameCDK4_MOUSE
FullNameCyclin-dependent kinase 4
TaxID10090
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCdk4

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016301 kinase activity
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
CDK4_MOUSECCND1_MOUSEBioGRID, DIP, I2D, IntAct, MINT12588994 12970760 16102793 16331266 16413468 16413469 16627785 16864783 17081987 17699765 17940036 17948060 19409388 20150892 20516642 20951943 21242975 21306487 23707388 details
CDK4_MOUSERB_HUMANIntAct17045206 17349581 details
CDK4_MOUSEPP1G_MOUSEBioGRID, IntAct17274640 details
CDK4_MOUSEPURA_MOUSEBioGRID15707957 details
CDK4_MOUSESET_MOUSEBioGRID17309103 details
CDK4_MOUSERUNX3_HUMANBioGRID19351720 details
CDK4_MOUSERB_MOUSEBioGRID11254678 15158336 8547220 details
CDK4_MOUSECEBPA_MOUSEBioGRID11867521 15107404 20516642 details
CDK4_MOUSEH11_MOUSEBioGRID12007403 details
CDK4_MOUSEH12_MOUSEBioGRID12970760 details
CDK4_MOUSEHS90A_MOUSEBioGRID11867521 details
CDK4_MOUSEH15_MOUSEBioGRID16627785 details
CDK4_MOUSEMEF2D_HUMANBioGRID25733682 details
CDK4_MOUSEOTUD4_HUMANBioGRID31138677 details
CDK4_MOUSECDN1B_MOUSEBioGRID, DIP, IntAct11967266 16413468 17699765 19276117 8033213 8822197 details
CDK4_MOUSECCND3_MOUSEBioGRID, IntAct11254678 16413469 23948297 details
CDK4_MOUSECCND2_MOUSEBioGRID, IntAct16413469 23948297 9584157 details
CDK4_MOUSECCND1_HUMANMINT19409388 details
CDK4_MOUSERGL2_HUMANI2D21242975 details
CDK4_MOUSECDN1A_MOUSEBioGRID11967266 12970760 18729080 details
CDK4_MOUSEPSD10_MOUSEBioGRID20516642 details
CDK4_MOUSEPCNA_MOUSEBioGRID12970760 details
CDK4_MOUSEHSP7C_MOUSEBioGRID12588994 details
CDK4_MOUSECDC37_MOUSEBioGRID11867521 details
CDK4_MOUSECEP57_MOUSEBioGRID21306487 details