Entity Details

Primary name PDGFB_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP31240
EntryNamePDGFB_MOUSE
FullNamePlatelet-derived growth factor subunit B
TaxID10090
Evidenceevidence at transcript level
Length241
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPdgfb

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002548 monocyte chemotaxis
GO:0003104 positive regulation of glomerular filtration
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005518 collagen binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0006929 substrate-dependent cell migration
GO:0007416 synapse assembly
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0016322 neuron remodeling
GO:0016323 basolateral plasma membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021782 glial cell development
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030425 dendrite
GO:0031954 positive regulation of protein autophosphorylation
GO:0032091 negative regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032967 positive regulation of collagen biosynthetic process
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 paracrine signaling
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042056 chemoattractant activity
GO:0042462 eye photoreceptor cell development
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 positive regulation of DNA replication
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840 positive regulation of mitotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045977 positive regulation of mitotic cell cycle, embryonic
GO:0046982 protein heterodimerization activity
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050921 positive regulation of chemotaxis
GO:0051781 positive regulation of cell division
GO:0060041 retina development in camera-type eye
GO:0060326 cell chemotaxis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0070851 growth factor receptor binding
GO:0071363 cellular response to growth factor stimulus
GO:0071506 cellular response to mycophenolic acid
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264 metanephric glomerular endothelium development
GO:0072593 reactive oxygen species metabolic process
GO:0090280 positive regulation of calcium ion import
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1904899 positive regulation of hepatic stellate cell proliferation
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
GO:1905176 positive regulation of vascular associated smooth muscle cell dedifferentiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000591 positive regulation of metanephric mesenchymal cell migration

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000072 PDGF/VEGF domainDomainDomain
IPR006782 Platelet-derived growth factor, N-terminalDomainDomain
IPR015583 Platelet-derived growth factor subunit BFamilyFamily
IPR023581 Platelet-derived growth factor, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PDGFB_MOUSEPGFRB_MOUSEIntAct20738866 details