Entity Details

Primary name NOTC4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP31695
EntryNameNOTC4_MOUSE
FullNameNeurogenic locus notch homolog protein 4
TaxID10090
Evidenceevidence at protein level
Length1964
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesNotch4

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001837 epithelial to mesenchymal transition
GO:0001886 endothelial cell morphogenesis
GO:0001944 vasculature development
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007219 Notch signaling pathway
GO:0008593 regulation of Notch signaling pathway
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030879 mammary gland development
GO:0031410 cytoplasmic vesicle
GO:0032880 regulation of protein localization
GO:0038023 signaling receptor activity
GO:0045446 endothelial cell differentiation
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0048845 venous blood vessel morphogenesis
GO:0060354 negative regulation of cell adhesion molecule production
GO:0070613 regulation of protein processing
GO:1903849 positive regulation of aorta morphogenesis
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022355 Neurogenic locus Notch 4FamilyFamily
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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