Entity Details

Primary name AKT1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP31750
EntryNameAKT1_MOUSE
FullNameRAC-alpha serine/threonine-protein kinase
TaxID10090
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesAkt1

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002931 response to ischemia
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007281 germ cell development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008637 apoptotic mitochondrial changes
GO:0008643 carbohydrate transport
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0010507 negative regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010763 positive regulation of fibroblast migration
GO:0010765 positive regulation of sodium ion transport
GO:0010907 positive regulation of glucose metabolic process
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0010951 negative regulation of endopeptidase activity
GO:0010975 regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015630 microtubule cytoskeleton
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021510 spinal cord development
GO:0030030 cell projection organization
GO:0030163 protein catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030235 nitric-oxide synthase regulator activity
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0031397 negative regulation of protein ubiquitination
GO:0031641 regulation of myelination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031982 vesicle
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032079 positive regulation of endodeoxyribonuclease activity
GO:0032091 negative regulation of protein binding
GO:0032094 response to food
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032287 peripheral nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032794 GTPase activating protein binding
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0032929 negative regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034405 response to fluid shear stress
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036064 ciliary basal body
GO:0036294 cellular response to decreased oxygen levels
GO:0038061 NIK/NF-kappaB signaling
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046329 negative regulation of JNK cascade
GO:0046622 positive regulation of organ growth
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051721 protein phosphatase 2A binding
GO:0060416 response to growth hormone
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060716 labyrinthine layer blood vessel development
GO:0070141 response to UV-A
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0071889 14-3-3 protein binding
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 execution phase of apoptosis
GO:0099104 potassium channel activator activity
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110099 negative regulation of calcium import into the mitochondrion
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900182 positive regulation of protein localization to nucleus
GO:1901653 cellular response to peptide
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903715 regulation of aerobic respiration
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990418 response to insulin-like growth factor stimulus
GO:2000010 positive regulation of protein localization to cell surface
GO:2000402 negative regulation of lymphocyte migration
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR034676 Protein kinase B alpha, catalytic domainDomainDomain
IPR039026 Protein Kinase B, pleckstrin homology domainDomainDomain
IPR039027 Serine/threonine-protein kinase RAC alphaFamilyFamily

Diseases

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Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
AKT1_MOUSETRIB3_MOUSEIntAct12791994 details
AKT1_MOUSEPEPL_MOUSEIntAct15102471 details
AKT1_MOUSEPDE3A_MOUSEMINT17124499 details
AKT1_MOUSEARRB2_HUMANIntAct16051150 details
AKT1_MOUSEARRB1_HUMANIntAct16051150 details
AKT1_MOUSEPTN1_HUMANMINT11579209 details
AKT1_MOUSECALM1_HUMANBioGRID15840729 details
AKT1_MOUSECALM2_HUMANBioGRID15840729 details
AKT1_MOUSECALM3_HUMANBioGRID15840729 details
AKT1_MOUSEB2L11_HUMANBioGRID16282323 details
AKT1_MOUSEH2B1C_MOUSEBioGRID11435472 details
AKT1_MOUSEH2B2B_MOUSEBioGRID9582374 details
AKT1_MOUSEAKT1_MOUSEBioGRID7891724 details
AKT1_MOUSEPRGC1_MOUSEBioGRID17554339 details
AKT1_MOUSEKCD20_MOUSEBioGRID24156551 details
AKT1_MOUSESOX2_MOUSEBioGRID25042802 details
AKT1_MOUSECTND1_MOUSEBioGRID17993462 details
AKT1_MOUSEGRDN_MOUSEBioGRID15753085 details
AKT1_MOUSEGSK3A_MOUSEBioGRID18851840 20576936 21084607 details
AKT1_MOUSEGSK3B_MOUSEBioGRID18851840 20576936 21084607 32325033 details
AKT1_MOUSEHS90A_HUMANBioGRID19662498 details
AKT1_MOUSEPDPK1_HUMANBioGRID19662498 details
AKT1_MOUSEPARVB_MOUSEBioGRID20164304 details
AKT1_MOUSEUBP1_HUMANBioGRID32133736 details
AKT1_MOUSEUBP11_HUMANBioGRID32133736 details
AKT1_MOUSEOTUB2_HUMANBioGRID32133736 details
AKT1_MOUSEOTUD5_HUMANBioGRID32133736 details
AKT1_MOUSEOTU6A_HUMANBioGRID32133736 details
AKT1_MOUSEM3K5_MOUSEIntAct11154276 details
AKT1_MOUSESTK4_HUMANMINT17932490 details
AKT1_MOUSELMNA_MOUSEDIP, MINT18388859 23686339 details
AKT1_MOUSESIN1_MOUSEMINT18566586 details
AKT1_MOUSEUBB_MOUSEMINT18566586 details
AKT1_MOUSEUBC_MOUSEMINT18566586 details
AKT1_MOUSERS27A_MOUSEMINT18566586 details
AKT1_MOUSERL40_MOUSEMINT18566586 details
AKT1_MOUSEHS90A_MOUSEBioGRID, MINT10995457 18566586 details
AKT1_MOUSESIR1_MOUSEIntAct21775285 details
AKT1_MOUSERICTR_HUMANI2D21339740 details
AKT1_MOUSEPREX1_HUMANI2D21339740 details
AKT1_MOUSEF110C_HUMANUniProt19698782 details
AKT1_MOUSECHIP_MOUSEBioGRID, DIP18292230 details
AKT1_MOUSESRC_MOUSEBioGRID, DIP19122674 details
AKT1_MOUSEARRB2_MOUSEBioGRID, DIP16051150 19122674 details
AKT1_MOUSEHDAC6_MOUSEBioGRID, IntAct24955524 details
AKT1_MOUSEBTBDA_MOUSEBioGRID18160256 details
AKT1_MOUSETRAF6_MOUSEBioGRID23907468 25808491 details
AKT1_MOUSEHS90B_MOUSEBioGRID10995457 details
AKT1_MOUSEP85A_MOUSEBioGRID24567360 details
AKT1_MOUSEHD_HUMANBioGRID15843398 details
AKT1_MOUSE2ABB_MOUSEBioGRID16051150 details
AKT1_MOUSEPP2AA_MOUSEBioGRID16051150 details
AKT1_MOUSEARRB1_MOUSEBioGRID16051150 19122674 details
AKT1_MOUSECLIP3_MOUSEBioGRID19139280 details
AKT1_MOUSEMK14_MOUSEBioGRID17015449 details
AKT1_MOUSEHSPB2_MOUSEBioGRID17015449 details
AKT1_MOUSEMAPK2_MOUSEBioGRID17015449 details
AKT1_MOUSEHSPB1_MOUSEBioGRID12740362 details
AKT1_MOUSEVHL_HUMANBioGRID27563096 details
AKT1_MOUSEVHL_MOUSEBioGRID27563096 details
AKT1_MOUSEILK_MOUSEBioGRID20164304 details
AKT1_MOUSEIWS1_HUMANBioGRID24462114 details
AKT1_MOUSEAKTS1_MOUSEBioGRID24462114 details
AKT1_MOUSEM4K4_MOUSEBioGRID24462114 details
AKT1_MOUSETSC1_MOUSEBioGRID32133736 details