Entity Details

Primary name MP2K1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP31938
EntryNameMP2K1_MOUSE
FullNameDual specificity mitogen-activated protein kinase kinase 1
TaxID10090
Evidenceevidence at protein level
Length393
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMap2k1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0003056 regulation of vascular associated smooth muscle contraction
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014069 postsynaptic density
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030878 thyroid gland development
GO:0031267 small GTPase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032402 melanosome transport
GO:0032839 dendrite cytoplasm
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111 negative regulation of homotypic cell-cell adhesion
GO:0042593 glucose homeostasis
GO:0043204 perikaryon
GO:0043539 protein serine/threonine kinase activator activity
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045933 positive regulation of muscle contraction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0047485 protein N-terminus binding
GO:0047496 vesicle transport along microtubule
GO:0048313 Golgi inheritance
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0048678 response to axon injury
GO:0048679 regulation of axon regeneration
GO:0048812 neuron projection morphogenesis
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0051384 response to glucocorticoid
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070328 triglyceride homeostasis
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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