Entity Details

Primary name PE2R4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP32240
EntryNamePE2R4_MOUSE
FullNameProstaglandin E2 receptor EP4 subtype
TaxID10090
Evidenceevidence at transcript level
Length513
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPtger4

GO terms

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GOName
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0001934 positive regulation of protein phosphorylation
GO:0002792 negative regulation of peptide secretion
GO:0004957 prostaglandin E receptor activity
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007254 JNK cascade
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010727 negative regulation of hydrogen peroxide metabolic process
GO:0010840 regulation of circadian sleep/wake cycle, wakefulness
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0030278 regulation of ossification
GO:0031965 nuclear membrane
GO:0032496 response to lipopolysaccharide
GO:0032690 negative regulation of interleukin-1 alpha production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0032757 positive regulation of interleukin-8 production
GO:0033624 negative regulation of integrin activation
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042093 T-helper cell differentiation
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042466 chemokinesis
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043025 neuronal cell body
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0044306 neuron projection terminus
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045780 positive regulation of bone resorption
GO:0045785 positive regulation of cell adhesion
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0050714 positive regulation of protein secretion
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051492 regulation of stress fiber assembly
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0060348 bone development
GO:0070257 positive regulation of mucus secretion
GO:0070371 ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0090303 positive regulation of wound healing
GO:0097070 ductus arteriosus closure
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1904336 negative regulation of ductus arteriosus closure
GO:1904348 negative regulation of small intestine smooth muscle contraction
GO:1904364 positive regulation of calcitonin secretion
GO:1904367 positive regulation of chemokinesis
GO:1904460 positive regulation of substance P secretion
GO:1904466 positive regulation of matrix metallopeptidase secretion
GO:1904471 negative regulation of endothelin production
GO:1904496 positive regulation of substance P secretion, neurotransmission
GO:2000386 positive regulation of ovarian follicle development
GO:2000388 positive regulation of antral ovarian follicle growth
GO:2000391 positive regulation of neutrophil extravasation
GO:2000420 negative regulation of eosinophil extravasation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001244 Prostaglandin DP receptorFamilyFamily
IPR001758 Prostanoid EP4 receptorFamilyFamily
IPR008365 Prostanoid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Interactions

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