Entity Details

Primary name MMP2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP33434
EntryNameMMP2_MOUSE
FullName72 kDa type IV collagenase
TaxID10090
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesMmp2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001955 blood vessel maturation
GO:0001957 intramembranous ossification
GO:0001968 fibronectin binding
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006979 response to oxidative stress
GO:0007162 negative regulation of cell adhesion
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0007568 aging
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009612 response to mechanical stimulus
GO:0014012 peripheral nervous system axon regeneration
GO:0016477 cell migration
GO:0030017 sarcomere
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0034614 cellular response to reactive oxygen species
GO:0035987 endodermal cell differentiation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045089 positive regulation of innate immune response
GO:0045906 negative regulation of vasoconstriction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048705 skeletal system morphogenesis
GO:0048771 tissue remodeling
GO:0060325 face morphogenesis
GO:0060346 bone trabecula formation
GO:0060740 prostate gland epithelium morphogenesis
GO:0071230 cellular response to amino acid stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071492 cellular response to UV-A
GO:1904645 response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000562 Fibronectin type II domainDomainDomain
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028708 72kDa type IV collagenaseFamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MMP2_MOUSESRC8_MOUSEmbinfo20952093 details