Entity Details

Primary name DPOLA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP33609
EntryNameDPOLA_MOUSE
FullNameDNA polymerase alpha catalytic subunit
TaxID10090
Evidenceevidence at protein level
Length1465
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPola1

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000731 DNA synthesis involved in DNA repair
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0016363 nuclear matrix
GO:0017076 purine nucleotide binding
GO:0019103 pyrimidine nucleotide binding
GO:0019901 protein kinase binding
GO:0032479 regulation of type I interferon production
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0071897 DNA biosynthetic process
GO:1902975 mitotic DNA replication initiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domainDomainDomain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domainDomainDomain
IPR006172 DNA-directed DNA polymerase, family BFamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alphaDomainDomain
IPR017964 DNA-directed DNA polymerase, family B, conserved siteSiteConserved site
IPR023211 DNA polymerase, palm domain superfamilyFamilyHomologous superfamily
IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domainDomainDomain
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR038256 DNA polymerase alpha, zinc finger domain superfamilyFamilyHomologous superfamily
IPR042087 DNA polymerase family B, thumb domainFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions