Entity Details

Primary name DOT1L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TEK3
EntryNameDOT1L_HUMAN
FullNameHistone-lysine N-methyltransferase, H3 lysine-79 specific
TaxID9606
Evidenceevidence at protein level
Length1537
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesDOT1L

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006281 DNA repair
GO:0006348 chromatin silencing at telomere
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010467 gene expression
GO:0018024 histone-lysine N-methyltransferase activity
GO:0031151 histone methyltransferase activity (H3-K79 specific)
GO:0032200 telomere organization
GO:0032991 protein-containing complex
GO:0034729 histone H3-K79 methylation
GO:0042054 histone methyltransferase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:2000677 regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR021169 Histone H3-K79 methyltransferase, metazoaFamilyFamily
IPR025789 Histone-lysine N-methyltransferase DOT1 domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR030445 Histone H3-K79 methyltransferaseFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DOT1L_HUMANAF9_MOUSEDIP23260655 details