Entity Details

Primary name FAK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP34152
EntryNameFAK1_MOUSE
FullNameFocal adhesion kinase 1
TaxID10090
Evidenceevidence at protein level
Length1052
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPtk2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001725 stress fiber
GO:0001764 neuron migration
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003779 actin binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007097 nuclear migration
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007254 JNK cascade
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008432 JUN kinase binding
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010632 regulation of epithelial cell migration
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016604 nuclear body
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030644 cellular chloride ion homeostasis
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0036064 ciliary basal body
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043542 endothelial cell migration
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045667 regulation of osteoblast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050766 positive regulation of phagocytosis
GO:0050771 negative regulation of axonogenesis
GO:0050806 positive regulation of synaptic transmission
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060252 positive regulation of glial cell proliferation
GO:0060396 growth hormone receptor signaling pathway
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090303 positive regulation of wound healing
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0120041 positive regulation of macrophage proliferation
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR005189 Focal adhesion kinase, targeting (FAT) domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamilyFamilyHomologous superfamily
IPR041390 Focal adhesion kinase, N-terminalDomainDomain
IPR041784 FAK1/PYK2, FERM domain C-lobeDomainDomain

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
FAK1_MOUSEBCAR1_MOUSEBioGRID, IntAct, MINT18233957 7479864 9038154 details
FAK1_MOUSEFYN_MOUSEBioGRID, IntAct15102471 17875741 details
FAK1_MOUSEGRB7_MOUSEMINT17318180 details
FAK1_MOUSEPTN1_HUMANMINT9418872 details
FAK1_MOUSEPAXI_HUMANBioGRID, mbinfo10417825 20150423 details
FAK1_MOUSEEFS_MOUSEBioGRID9038154 9750131 details
FAK1_MOUSEEFS_HUMANBioGRID9750131 details
FAK1_MOUSEGATA4_MOUSEBioGRID22734001 details
FAK1_MOUSEFAK1_MOUSEBioGRID10431817 details
FAK1_MOUSESRC_MOUSEBioGRID, MINT10362356 10931187 16966330 18233957 32325033 details
FAK1_MOUSEPAXI_MOUSEBioGRID, IntAct, mbinfo, MINT10931187 15138291 16298995 20308429 21289086 details
FAK1_MOUSEEPHB2_MOUSEIntAct16298995 details
FAK1_MOUSEGRB2_MOUSEIntAct, MINT16298995 7997267 details
FAK1_MOUSENRP1_MOUSEMINT18464795 details
FAK1_MOUSEL1CAM_MOUSEMINT18464795 details
FAK1_MOUSESRC_HUMANMINT18464795 9148935 details
FAK1_MOUSEPTN11_MOUSEMINT19698715 details
FAK1_MOUSEDVLP1_HUMANMINT20224554 details
FAK1_MOUSEGRB2_HUMANMINT8816475 9148935 details
FAK1_MOUSEBCAR1_HUMANmbinfo20150423 details
FAK1_MOUSEARP3_MOUSEmbinfo17721515 details
FAK1_MOUSEWASL_MOUSEBioGRID, mbinfo17721515 32325033 details
FAK1_MOUSEDYN2_MOUSEBioGRID, mbinfo15895076 32325033 details
FAK1_MOUSEBCL2_MOUSEBioGRID10417825 details
FAK1_MOUSESRBS1_MOUSEBioGRID9461600 details
FAK1_MOUSESOCS3_MOUSEBioGRID14517242 details
FAK1_MOUSELPXN_MOUSEBioGRID12674328 details
FAK1_MOUSEJIP3_MOUSEBioGRID16141199 details
FAK1_MOUSETBK1_MOUSEBioGRID31690171 details
FAK1_MOUSEKCNB1_MOUSEBioGRID18615577 details