Entity Details

Primary name FRS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WU20
EntryNameFRS2_HUMAN
FullNameFibroblast growth factor receptor substrate 2
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesFRS2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001702 gastrulation with mouth forming second
GO:0001759 organ induction
GO:0003281 ventricular septum development
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007405 neuroblast proliferation
GO:0007411 axon guidance
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008595 anterior/posterior axis specification, embryo
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0019211 phosphatase activator activity
GO:0030900 forebrain development
GO:0042981 regulation of apoptotic process
GO:0046619 lens placode formation involved in camera-type eye formation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050678 regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307 lens fiber cell development
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:2000726 negative regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Endomembrane system

Domains

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DomainNameCategoryType
IPR002404 IRS-type PTB domainDomainDomain
IPR038742 FRS2, PTB domainDomainDomain

Diseases

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Interactions

3 interactions