Entity Details

Primary name MMP12_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP34960
EntryNameMMP12_MOUSE
FullNameMacrophage metalloelastase
TaxID10090
Evidenceevidence at protein level
Length473
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesMmp12

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001046 core promoter sequence-specific DNA binding
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006508 proteolysis
GO:0006606 protein import into nucleus
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0032727 positive regulation of interferon-alpha production
GO:0035313 wound healing, spreading of epidermal cells
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048286 lung alveolus development
GO:0050691 regulation of defense response to virus by host
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060309 elastin catabolic process
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060435 bronchiole development
GO:0098586 cellular response to virus
GO:1901163 regulation of trophoblast cell migration
GO:1904905 negative regulation of endothelial cell-matrix adhesion via fibronectin

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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