Entity Details

Primary name PTN11_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35235
EntryNamePTN11_MOUSE
FullNameTyrosine-protein phosphatase non-receptor type 11
TaxID10090
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPtpn11

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0001784 phosphotyrosine residue binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021697 cerebellar cortex formation
GO:0030159 signaling receptor complex adaptor activity
GO:0030220 platelet formation
GO:0030971 receptor tyrosine kinase binding
GO:0031748 D1 dopamine receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032528 microvillus organization
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0036302 atrioventricular canal development
GO:0038127 ERBB signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043254 regulation of protein-containing complex assembly
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044853 plasma membrane raft
GO:0045296 cadherin binding
GO:0045778 positive regulation of ossification
GO:0045931 positive regulation of mitotic cell cycle
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048609 multicellular organismal reproductive process
GO:0048659 smooth muscle cell proliferation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0051894 positive regulation of focal adhesion assembly
GO:0060020 Bergmann glial cell differentiation
GO:0060125 negative regulation of growth hormone secretion
GO:0060325 face morphogenesis
GO:0061582 intestinal epithelial cell migration
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904385 cellular response to angiotensin
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
PTN11_MOUSESMRC1_MOUSEIntAct15102471 details
PTN11_MOUSEHEAT6_MOUSEIntAct15102471 details
PTN11_MOUSELC7L3_MOUSEIntAct15102471 details
PTN11_MOUSEKIT_HUMANIntAct7523381 details
PTN11_MOUSEGRB2_HUMANIntAct, MINT11432792 11684012 7522233 7523381 8959326 details
PTN11_MOUSEABI1_HUMANMINT20598684 details
PTN11_MOUSEGRB2_MOUSEBioGRID, IntAct, MINT10995764 11684012 23452850 details
PTN11_MOUSEGRB7_HUMANMINT8622870 details
PTN11_MOUSECTND1_MOUSEMINT9670943 details
PTN11_MOUSELIRB4_MOUSEBioGRID, DIP18550825 9973385 details
PTN11_MOUSETIE2_MOUSEBioGRID10521483 details
PTN11_MOUSESHPS1_MOUSEBioGRID11970986 15699129 18450421 8810330 9507023 details
PTN11_MOUSEITSN1_MOUSEBioGRID24216759 details
PTN11_MOUSESPY2_HUMANBioGRID24216759 details
PTN11_MOUSEP85A_MOUSEBioGRID10995764 32325033 details
PTN11_MOUSEGASR_HUMANMINT16963136 details
PTN11_MOUSEFAK1_MOUSEMINT19698715 details
PTN11_MOUSEPTN11_MOUSEMINT11684012 details
PTN11_MOUSESOCS3_MOUSEMINT12403768 details
PTN11_MOUSECEAM1_MOUSEMINT9867848 details
PTN11_MOUSEJAK2_MOUSEMINT17027227 details
PTN11_MOUSENTRK2_MOUSEMINT21364532 details
PTN11_MOUSEI23O1_MOUSEInnateDB21804557 details
PTN11_MOUSEFES_MOUSEInnateDB22522491 details
PTN11_MOUSETRAF6_MOUSEInnateDB22522491 details
PTN11_MOUSECBL_MOUSEBioGRID, IntAct23374343 32325033 9393882 details
PTN11_MOUSELIRB3_MOUSEDIP, IntAct22660330 24052308 details
PTN11_MOUSEITCH_MOUSEBioGRID20417562 details
PTN11_MOUSESHIP1_MOUSEBioGRID9393882 details
PTN11_MOUSESHC1_MOUSEBioGRID9393882 details
PTN11_MOUSEABL1_MOUSEBioGRID9393882 details
PTN11_MOUSEFRS2_MOUSEBioGRID12974390 15870281 details
PTN11_MOUSEFAS_MOUSEBioGRID23269672 32325033 details
PTN11_MOUSECOP1_MOUSEBioGRID23269672 details
PTN11_MOUSEBTLA_MOUSEBioGRID15568026 details
PTN11_MOUSETNR14_MOUSEBioGRID15568026 details
PTN11_MOUSELEPR_MOUSEBioGRID15520383 details
PTN11_MOUSEGAB1_MOUSEBioGRID12808090 15273746 25159185 details
PTN11_MOUSE1433B_MOUSEBioGRID12937170 details
PTN11_MOUSECLM8_MOUSEBioGRID12893283 details
PTN11_MOUSEEGFR_MOUSEBioGRID23027125 details
PTN11_MOUSEDAB1_MOUSEBioGRID15062102 details
PTN11_MOUSECBLB_MOUSEBioGRID26416283 details
PTN11_MOUSEFRS2_HUMANBioGRID25159185 details
PTN11_MOUSEGHR_MOUSEBioGRID9507023 details
PTN11_MOUSEIL6RB_MOUSEBioGRID9507023 details