Entity Details

Primary name DDX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92499
EntryNameDDX1_HUMAN
FullNameATP-dependent RNA helicase DDX1
TaxID9606
Evidenceevidence at protein level
Length740
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDDX1

GO terms

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GOName
GO:0000245 spliceosomal complex assembly
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006446 regulation of translational initiation
GO:0007275 multicellular organism development
GO:0008143 poly(A) binding
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0016032 viral process
GO:0032508 DNA duplex unwinding
GO:0033677 DNA/RNA helicase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0071920 cleavage body
GO:0072669 tRNA-splicing ligase complex
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1903608 protein localization to cytoplasmic stress granule
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014014 RNA helicase, DEAD-box type, Q motifDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DDX1_HUMANMK13_MOUSEBioGRID19135240 details
DDX1_HUMANFXL16_MOUSEBioGRID24390425 details