Entity Details

Primary name TOPB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92547
EntryNameTOPB1_HUMAN
FullNameDNA topoisomerase 2-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length1522
SequenceStatuscomplete
DateCreated2005-04-26
DateModified2021-06-02

Ontological Relatives

GenesTOPBP1

GO terms

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GOName
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001673 male germ cell nucleus
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0008022 protein C-terminus binding
GO:0010212 response to ionizing radiation
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0016605 PML body
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR035960 Secretoglobin superfamilyFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TOPB1_HUMANPPARG_MOUSEBioGRID27197753 details
TOPB1_HUMANHUS1_MOUSEBioGRID25911100 details