Entity Details

Primary name ESR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92731
EntryNameESR2_HUMAN
FullNameEstrogen receptor beta
TaxID9606
Evidenceevidence at protein level
Length530
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesESR2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0030284 estrogen receptor activity
GO:0030308 negative regulation of cell growth
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0034056 estrogen response element binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048019 receptor antagonist activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0071392 cellular response to estradiol stimulus

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR021064 Estrogen receptor beta, N-terminalDomainDomain
IPR024178 Estrogen receptor/oestrogen-related receptorFamilyFamily
IPR028355 Estrogen receptor beta/gammaFamilyFamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB01108 TrilostaneDrugbanksmall molecule
DB01196 EstramustineDrugbanksmall molecule
DB01428 OxybenzoneDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01878 BenzophenoneDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB02757 PyrazoleDrugbanksmall molecule
DB02983 Para-Mercury-Benzenesulfonic AcidDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB03860 ICI-164384Drugbanksmall molecule
DB03882 5-Alpha-Androstane-3-Beta,17beta-DiolDrugbanksmall molecule
DB04020 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)PhenolDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04468 AfimoxifeneDrugbanksmall molecule
DB04573 EstriolDrugbanksmall molecule
DB04574 Estrone sulfateDrugbanksmall molecule
DB05052 MF101Drugbanksmall molecule
DB05882 CHF 4227Drugbanksmall molecule
DB05966 TAS-108Drugbanksmall molecule
DB06202 LasofoxifeneDrugbanksmall molecule
DB06249 ArzoxifeneDrugbanksmall molecule
DB06401 BazedoxifeneDrugbanksmall molecule
DB06832 PrinaberelDrugbanksmall molecule
DB06875 ERB-196Drugbanksmall molecule
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDrugbanksmall molecule
DB06937 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLDrugbanksmall molecule
DB07032 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OLDrugbanksmall molecule
DB07036 (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-olDrugbanksmall molecule
DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLDrugbanksmall molecule
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMEDrugbanksmall molecule
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILEDrugbanksmall molecule
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONEDrugbanksmall molecule
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLDrugbanksmall molecule
DB07638 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB07702 17alpha-EstriolDrugbanksmall molecule
DB07757 (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-oneDrugbanksmall molecule
DB07933 ErteberelDrugbanksmall molecule
DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB09086 EugenolDrugbanksmall molecule
DB09535 OctocryleneDrugbanksmall molecule
DB11219 EnzacameneDrugbanksmall molecule
DB11674 EquolDrugbanksmall molecule
DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14641 Estriol tripropionateDrugbanksmall molecule
DB15690 Fluoroestradiol F-18Drugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ESR2_HUMANNCOR1_MOUSEIntAct12904255 details