Entity Details

Primary name HDAC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92769
EntryNameHDAC2_HUMAN
FullNameHistone deacetylase 2
TaxID9606
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesHDAC2

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001975 response to amphetamine
GO:0003300 cardiac muscle hypertrophy
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006338 chromatin remodeling
GO:0007596 blood coagulation
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016575 histone deacetylation
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031000 response to caffeine
GO:0031072 heat shock protein binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032496 response to lipopolysaccharide
GO:0032732 positive regulation of interleukin-1 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032922 circadian regulation of gene expression
GO:0032967 positive regulation of collagen biosynthetic process
GO:0032991 protein-containing complex
GO:0033558 protein deacetylase activity
GO:0034605 cellular response to heat
GO:0035094 response to nicotine
GO:0035098 ESC/E(Z) complex
GO:0042220 response to cocaine
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042733 embryonic digit morphogenesis
GO:0042826 histone deacetylase binding
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048149 behavioral response to ethanol
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051059 NF-kappaB binding
GO:0055093 response to hyperoxia
GO:0060789 hair follicle placode formation
GO:0061000 negative regulation of dendritic spine development
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070301 cellular response to hydrogen peroxide
GO:0070829 heterochromatin maintenance
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071300 cellular response to retinoic acid
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902437 positive regulation of male mating behavior
GO:1903351 cellular response to dopamine
GO:1990841 promoter-specific chromatin binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000757 negative regulation of peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00175 PravastatinDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01223 AminophyllineDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB02546 VorinostatDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05223 PracinostatDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB09091 TixocortolDrugbanksmall molecule
DB11830 MocetinostatDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink