Entity Details

Primary name CBP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92793
EntryNameCBP_HUMAN
FullNameCREB-binding protein
TaxID9606
Evidenceevidence at protein level
Length2442
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCREBBP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000123 histone acetyltransferase complex
GO:0000785 chromatin
GO:0001666 response to hypoxia
GO:0002039 p53 binding
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008589 regulation of smoothened signaling pathway
GO:0016032 viral process
GO:0016407 acetyltransferase activity
GO:0016573 histone acetylation
GO:0016604 nuclear body
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0019216 regulation of lipid metabolic process
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031490 chromatin DNA binding
GO:0031648 protein destabilization
GO:0032481 positive regulation of type I interferon production
GO:0034644 cellular response to UV
GO:0042592 homeostatic process
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043426 MRF binding
GO:0045637 regulation of myeloid cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:0065003 protein-containing complex assembly
GO:1900034 regulation of cellular response to heat
GO:1904837 beta-catenin-TCF complex assembly
GO:1990258 histone glutamine methylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000197 Zinc finger, TAZ-typeDomainDomain
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR001487 BromodomainDomainDomain
IPR003101 Coactivator CBP, KIX domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010303 CREB-binding protein/p300, atypical RING domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013178 Histone acetyltransferase Rtt109/CBPFamilyFamily
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlockingDomainDomain
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR031162 CBP/p300-type histone acetyltransferase domainDomainDomain
IPR035898 TAZ domain superfamilyFamilyHomologous superfamily
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR036529 Coactivator CBP, KIX domain superfamilyFamilyHomologous superfamily
IPR037073 Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamilyFamilyHomologous superfamily
IPR038547 CBP/p300, atypical RING domain superfamilyFamilyHomologous superfamily
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08655 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONEDrugbanksmall molecule

Interactions

4 interactions