Entity Details

Primary name KAT2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92831
EntryNameKAT2B_HUMAN
FullNameHistone acetyltransferase KAT2B
TaxID9606
Evidenceevidence at protein level
Length832
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesKAT2B

GO terms

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GOName
GO:0000125 PCAF complex
GO:0000776 kinetochore
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0004145 diamine N-acetyltransferase activity
GO:0004402 histone acetyltransferase activity
GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010835 regulation of protein ADP-ribosylation
GO:0016032 viral process
GO:0016407 acetyltransferase activity
GO:0016579 protein deubiquitination
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019901 protein kinase binding
GO:0031672 A band
GO:0031674 I band
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0042641 actomyosin
GO:0042826 histone deacetylase binding
GO:0043966 histone H3 acetylation
GO:0043970 histone H3-K9 acetylation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045747 positive regulation of Notch signaling pathway
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046600 negative regulation of centriole replication
GO:0048511 rhythmic process
GO:0060173 limb development
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:2000233 negative regulation of rRNA processing

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000182 GNAT domainDomainDomain
IPR001487 BromodomainDomainDomain
IPR009464 PCAF, N-terminalDomainDomain
IPR016181 Acyl-CoA N-acyltransferaseFamilyHomologous superfamily
IPR016376 Histone acetyltransferase GCN5/PCAFFamilyFamily
IPR018359 Bromodomain, conserved siteSiteConserved site
IPR036427 Bromodomain-like superfamilyFamilyHomologous superfamily
IPR037800 Histone acetyltransferase GCN5FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01992 Coenzyme ADrugbanksmall molecule
DB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONEDrugbanksmall molecule
DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINEDrugbanksmall molecule