Entity Details

Primary name B2CL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92843
EntryNameB2CL2_HUMAN
FullNameBcl-2-like protein 2
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBCL2L2

GO terms

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GOName
GO:0005741 mitochondrial outer membrane
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097718 disordered domain specific binding
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4DomainDomain
IPR013280 Apoptosis regulator, Bcl-WFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12340 NavitoclaxDrugbanksmall molecule

Interactions

4 interactions