Entity Details

Primary name NMDZ1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35438
EntryNameNMDZ1_MOUSE
FullNameGlutamate receptor ionotropic, NMDA 1
TaxID10090
Evidenceevidence at protein level
Length938
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesGrin1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001661 conditioned taste aversion
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 NMDA glutamate receptor activity
GO:0005102 signaling receptor binding
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007268 chemical synaptic transmission
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008021 synaptic vesicle
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0008542 visual learning
GO:0009986 cell surface
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010646 regulation of cell communication
GO:0010942 positive regulation of cell death
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0016020 membrane
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0017146 NMDA selective glutamate receptor complex
GO:0018964 propylene metabolic process
GO:0019233 sensory perception of pain
GO:0019899 enzyme binding
GO:0019902 phosphatase binding
GO:0021586 pons maturation
GO:0021987 cerebral cortex development
GO:0022843 voltage-gated cation channel activity
GO:0022849 glutamate-gated calcium ion channel activity
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030658 transport vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0032590 dendrite membrane
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0035254 glutamate receptor binding
GO:0038023 signaling receptor activity
GO:0042165 neurotransmitter binding
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043278 response to morphine
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0044307 dendritic branch
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048511 rhythmic process
GO:0048814 regulation of dendrite morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050905 neuromuscular process
GO:0051290 protein heterotetramerization
GO:0051963 regulation of synapse assembly
GO:0055074 calcium ion homeostasis
GO:0060076 excitatory synapse
GO:0060079 excitatory postsynaptic potential
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0065003 protein-containing complex assembly
GO:0097060 synaptic membrane
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:1900149 positive regulation of Schwann cell migration
GO:1902952 positive regulation of dendritic spine maintenance
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903539 protein localization to postsynaptic membrane
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:1905429 response to glycine
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR018882 Calmodulin-binding domain C0, NMDA receptor, NR1 subunitDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
NMDZ1_MOUSEDLG4_MOUSEBioGRID, DIP, IntAct, MINT10862698 15663482 16554481 16601687 16635246 19240213 19243221 19455133 23760271 27507650 28671696 9647694 details
NMDZ1_MOUSENMDE2_MOUSEBioGRID, DIP, IntAct, MINT10862698 14645471 15663482 16554481 16635246 19243221 20141836 32033586 9003035 details
NMDZ1_MOUSENMDE1_MOUSEBioGRID, DIP, IntAct, MINT10862698 14645471 15663482 16554481 16635246 17018287 19243221 30284099 9003035 details
NMDZ1_MOUSECADH2_MOUSEBioGRID, IntAct, MINT10862698 16635246 17589506 details
NMDZ1_MOUSECALM1_MOUSEBioGRID, IntAct, MINT10862698 15663482 16635246 details
NMDZ1_MOUSECALM2_MOUSEBioGRID, IntAct, MINT10862698 15663482 16635246 details
NMDZ1_MOUSECALM3_MOUSEBioGRID, IntAct, MINT10862698 15663482 16635246 details
NMDZ1_MOUSEMYH10_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSECLH1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEKCC2A_MOUSEBioGRID, IntAct, MINT10862698 16635246 22234183 24734203 details
NMDZ1_MOUSEBSN_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEPFKAL_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEFUS_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSESLMAP_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSETP53B_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEAINX_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEDLG1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEDP13A_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEZO1_MOUSEBioGRID, IntAct10862698 16635246 details
NMDZ1_MOUSEEXOC7_MOUSEMINT16601687 details
NMDZ1_MOUSEEXOC3_MOUSEMINT16601687 details
NMDZ1_MOUSEEXOC4_MOUSEMINT16601687 details
NMDZ1_MOUSELRP8_MOUSEIntAct16332682 details
NMDZ1_MOUSEEPHB2_MOUSEDIP21508957 details
NMDZ1_MOUSESYGP1_MOUSEBioGRID, IntAct10862698 27507650 28671696 28706196 details
NMDZ1_MOUSEPSN1_MOUSEMINT32033586 details
NMDZ1_MOUSEAKAP5_MOUSEBioGRID10862698 details
NMDZ1_MOUSEAKAP9_MOUSEBioGRID10862698 details
NMDZ1_MOUSEKS6A1_MOUSEBioGRID10862698 details
NMDZ1_MOUSERAP1A_MOUSEBioGRID10862698 details
NMDZ1_MOUSEP85A_MOUSEBioGRID10862698 details
NMDZ1_MOUSECTND1_MOUSEBioGRID10862698 details
NMDZ1_MOUSEACTC_MOUSEBioGRID10862698 details
NMDZ1_MOUSESPTA1_MOUSEBioGRID10862698 details
NMDZ1_MOUSEHSP7C_MOUSEBioGRID10862698 details
NMDZ1_MOUSETBA4A_MOUSEBioGRID10862698 details
NMDZ1_MOUSEAP2A_MOUSEBioGRID15663482 details
NMDZ1_MOUSENUMB_MOUSEBioGRID17589506 details
NMDZ1_MOUSESHC3_MOUSEBioGRID15716419 details
NMDZ1_MOUSEEPS8_MOUSEBioGRID17018287 details
NMDZ1_MOUSEGRIA1_MOUSEBioGRID17018287 details
NMDZ1_MOUSELRP1_MOUSEBioGRID23760271 details
NMDZ1_MOUSENEB2_MOUSEBioGRID28634551 30562941 details
NMDZ1_MOUSECTBP1_MOUSEBioGRID30284099 details