Entity Details

Primary name RAD50_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92878
EntryNameRAD50_HUMAN
FullNameDNA repair protein RAD50
TaxID9606
Evidenceevidence at protein level
Length1312
SequenceStatuscomplete
DateCreated2005-02-01
DateModified2021-06-02

Ontological Relatives

GenesRAD50

GO terms

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GOName
GO:0000019 regulation of mitotic recombination
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0000794 condensed nuclear chromosome
GO:0003677 DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007131 reciprocal meiotic recombination
GO:0016020 membrane
GO:0016032 viral process
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0030870 Mre11 complex
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0043047 single-stranded telomeric DNA binding
GO:0046872 metal ion binding
GO:0051880 G-quadruplex DNA binding
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904354 negative regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR004584 DNA repair protein Rad50, eukaryotesFamilyFamily
IPR013134 RAD50, zinc hookDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038729 Rad50/SbcC-type AAA domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
RAD50_HUMANNF2L2_MOUSEBioGRID21382013 details