Entity Details

Primary name TSP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35441
EntryNameTSP1_MOUSE
FullNameThrombospondin-1
TaxID10090
Evidenceevidence at protein level
Length1170
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001786 phosphatidylserine binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0003151 outflow tract morphogenesis
GO:0003197 endocardial cushion development
GO:0003417 growth plate cartilage development
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0006954 inflammatory response
GO:0006986 response to unfolded protein
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010757 negative regulation of plasminogen activation
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0016529 sarcoplasmic reticulum
GO:0017134 fibroblast growth factor binding
GO:0018149 peptide cross-linking
GO:0030141 secretory granule
GO:0030169 low-density lipoprotein particle binding
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0032026 response to magnesium ion
GO:0032695 negative regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034976 response to endoplasmic reticulum stress
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 laminin binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0048266 behavioral response to pain
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050431 transforming growth factor beta binding
GO:0050840 extracellular matrix binding
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0051897 positive regulation of protein kinase B signaling
GO:0051918 negative regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding
GO:0070487 monocyte aggregation
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071732 cellular response to nitric oxide
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001027 negative regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum
Sarcoplasmic reticulum
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001007 VWFC domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003367 Thrombospondin, type 3-like repeatRepeatRepeat
IPR008859 Thrombospondin, C-terminalDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017897 Thrombospondin, type 3 repeatRepeatRepeat
IPR028499 Thrombospondin-1FamilyFamily
IPR028974 TSP type-3 repeatFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TSP1_MOUSEATF6A_MOUSEIntAct22682248 details