Entity Details

Primary name IRS1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35569
EntryNameIRS1_MOUSE
FullNameInsulin receptor substrate 1
TaxID10090
Evidenceevidence at protein level
Length1233
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesIrs1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016042 lipid catabolic process
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030159 signaling receptor complex adaptor activity
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0031000 response to caffeine
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0034504 protein localization to nucleus
GO:0036064 ciliary basal body
GO:0042169 SH2 domain binding
GO:0042327 positive regulation of phosphorylation
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0070094 positive regulation of glucagon secretion
GO:0071398 cellular response to fatty acid
GO:0090275 negative regulation of somatostatin secretion

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR002404 IRS-type PTB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039011 Insulin receptor substrateFamilyFamily

Diseases

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Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
IRS1_MOUSENUCL_MOUSEMINT9813005 details
IRS1_MOUSEPTN1_HUMANMINT10751417 details
IRS1_MOUSEINSR_HUMANMINT12446583 details
IRS1_MOUSEGRB2_HUMANIntAct25814554 details
IRS1_MOUSEP55G_HUMANIntAct25814554 details
IRS1_MOUSEKS6B1_MOUSEBioGRID15249583 details
IRS1_MOUSECRK_MOUSEBioGRID9729467 details
IRS1_MOUSEFBX40_MOUSEBioGRID22033112 details
IRS1_MOUSEIGF1R_MOUSEBioGRID22033112 details
IRS1_MOUSEVIME_MOUSEBioGRID, IntAct15602769 26773517 details
IRS1_MOUSEPHIP_MOUSEUniProt11018022 details
IRS1_MOUSEP85A_MOUSEBioGRID, MINT12783867 14684612 14966267 15169905 15183122 15249583 15380067 16455755 18059474 18296638 20804756 27708159 8557661 details
IRS1_MOUSEASPP2_MOUSEIntAct17965023 details
IRS1_MOUSEASPP2_HUMANIntAct17965023 details
IRS1_MOUSEE2AK2_MOUSEIntAct20144759 details
IRS1_MOUSE1433E_MOUSEBioGRID, MINT16216880 16944949 details
IRS1_MOUSE1433B_MOUSEMINT11875115 9422753 details
IRS1_MOUSESIR1_MOUSEUniProt17901049 details
IRS1_MOUSEIGF1R_HUMANMINT22261717 details
IRS1_MOUSEMK08_MOUSEDIP16818881 details
IRS1_MOUSEMK09_MOUSEDIP16818881 details
IRS1_MOUSETRI72_MOUSEDIP23354051 details
IRS1_MOUSEUBB_MOUSEDIP23354051 details
IRS1_MOUSEUBC_MOUSEDIP23354051 details
IRS1_MOUSERS27A_MOUSEDIP23354051 details
IRS1_MOUSERL40_MOUSEDIP23354051 details
IRS1_MOUSESHC1_MOUSEIntAct11259577 details
IRS1_MOUSEGRB2_MOUSEIntAct11259577 details
IRS1_MOUSEHDAC2_MOUSEBioGRID15522123 details
IRS1_MOUSEINSR_MOUSEBioGRID15249583 details
IRS1_MOUSEIRS2_MOUSEBioGRID9729467 details
IRS1_MOUSERBX1_MOUSEBioGRID22033112 details
IRS1_MOUSEPK3CA_MOUSEBioGRID27708159 details
IRS1_MOUSEUBP7_MOUSEBioGRID27568561 details
IRS1_MOUSEPTEN_MOUSEBioGRID27568561 details
IRS1_MOUSEKPCZ_MOUSEBioGRID26773517 details
IRS1_MOUSESQSTM_MOUSEBioGRID26773517 details
IRS1_MOUSERAD51_MOUSEBioGRID15965906 details
IRS1_MOUSEP53_MOUSEBioGRID30578299 details