Entity Details

Primary name FOXA2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35583
EntryNameFOXA2_MOUSE
FullNameHepatocyte nuclear factor 3-beta
TaxID10090
Evidenceevidence at protein level
Length459
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFoxa2

GO terms

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GOName
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001705 ectoderm formation
GO:0001708 cell fate specification
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007389 pattern specification process
GO:0008134 transcription factor binding
GO:0008344 adult locomotory behavior
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0021533 cell differentiation in hindbrain
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0030193 regulation of blood coagulation
GO:0030324 lung development
GO:0031018 endocrine pancreas development
GO:0032525 somite rostral/caudal axis specification
GO:0033132 negative regulation of glucokinase activity
GO:0040019 positive regulation of embryonic development
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046332 SMAD binding
GO:0048382 mesendoderm development
GO:0048468 cell development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 connective tissue development
GO:0061987 negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0070741 response to interleukin-6
GO:0071276 cellular response to cadmium ion
GO:0071542 dopaminergic neuron differentiation
GO:0090009 primitive streak formation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000543 positive regulation of gastrulation
GO:2000971 negative regulation of detection of glucose

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR013638 Fork-head N-terminalDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR018533 Forkhead box protein, C-terminalDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FOXA2_MOUSEHIF1A_MOUSEIntAct20609350 details