Entity Details

Primary name PTN1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35821
EntryNamePTN1_MOUSE
FullNameTyrosine-protein phosphatase non-receptor type 1
TaxID10090
Evidenceevidence at protein level
Length432
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPtpn1

GO terms

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GOName
GO:0004725 protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006470 protein dephosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0008270 zinc ion binding
GO:0008286 insulin receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030061 mitochondrial crista
GO:0030100 regulation of endocytosis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030971 receptor tyrosine kinase binding
GO:0031410 cytoplasmic vesicle
GO:0031532 actin cytoskeleton reorganization
GO:0032991 protein-containing complex
GO:0033157 regulation of intracellular protein transport
GO:0034976 response to endoplasmic reticulum stress
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0036498 IRE1-mediated unfolded protein response
GO:0043407 negative regulation of MAP kinase activity
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046875 ephrin receptor binding
GO:0051721 protein phosphatase 2A binding
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0097443 sorting endosome
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PTN1_MOUSECALX_MOUSEBioGRID25586181 details
PTN1_MOUSEJAK2_MOUSEBioGRID11970898 details