Entity Details

Primary name OPTN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96CV9
EntryNameOPTN_HUMAN
FullNameOptineurin
TaxID9606
Evidenceevidence at protein level
Length577
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesOPTN

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000139 Golgi membrane
GO:0001920 negative regulation of receptor recycling
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0006914 autophagy
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0008022 protein C-terminus binding
GO:0008219 cell death
GO:0010508 positive regulation of autophagy
GO:0016032 viral process
GO:0030674 protein-macromolecule adaptor activity
GO:0031267 small GTPase binding
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0034067 protein localization to Golgi apparatus
GO:0034620 cellular response to unfolded protein
GO:0042802 identical protein binding
GO:0043001 Golgi to plasma membrane protein transport
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050829 defense response to Gram-negative bacterium
GO:0055038 recycling endosome membrane
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0090161 Golgi ribbon formation
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Recycling endosome

Domains

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DomainNameCategoryType
IPR021063 NF-kappa-B essential modulator NEMO, N-terminalDomainDomain
IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domainDomainDomain
IPR032939 OptineurinFamilyFamily
IPR034735 NEMO, Zinc fingerDomainDomain

Diseases

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Interactions

3 interactions