Entity Details

Primary name VGFR2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35918
EntryNameVGFR2_MOUSE
FullNameVascular endothelial growth factor receptor 2
TaxID10090
Evidenceevidence at protein level
Length1345
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesKdr

GO terms

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GOName
GO:0001936 regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0004713 protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0010629 negative regulation of gene expression
GO:0016239 positive regulation of macroautophagy
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030054 cell junction
GO:0030324 lung development
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045296 cadherin binding
GO:0045446 endothelial cell differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0071944 cell periphery
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:1903010 regulation of bone development
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0003158 endothelium development
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0016477 cell migration
GO:0019838 growth factor binding
GO:0030097 hemopoiesis
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038085 vascular endothelial growth factor binding
GO:0043025 neuronal cell body
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0048286 lung alveolus development
GO:0048812 neuron projection morphogenesis
GO:0051894 positive regulation of focal adhesion assembly
GO:0055074 calcium ion homeostasis
GO:0097443 sorting endosome
GO:1904881 cellular response to hydrogen sulfide
GO:2001214 positive regulation of vasculogenesis
GO:0001541 ovarian follicle development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003157 endocardium development
GO:0003416 endochondral bone growth
GO:0010595 positive regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0033674 positive regulation of kinase activity
GO:0035162 embryonic hemopoiesis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043129 surfactant homeostasis
GO:0045121 membrane raft
GO:0045165 cell fate commitment
GO:0045766 positive regulation of angiogenesis
GO:0048469 cell maturation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050927 positive regulation of positive chemotaxis
GO:0061042 vascular wound healing
GO:0070371 ERK1 and ERK2 cascade
GO:0001570 vasculogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007275 multicellular organism development
GO:0008360 regulation of cell shape
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0032008 positive regulation of TOR signaling
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060837 blood vessel endothelial cell differentiation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1901532 regulation of hematopoietic progenitor cell differentiation

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Early endosome
Endoplasmic reticulum
Cell membrane
Cytoplasmic vesicle
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041348 VEGFR-2, Transmembrane domainDomainDomain

Diseases

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