Entity Details

Primary name FMR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35922
EntryNameFMR1_MOUSE
FullNameSynaptic functional regulator FMR1
TaxID10090
Evidenceevidence at protein level
Length614
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000775 chromosome, centromeric region
GO:0001934 positive regulation of protein phosphorylation
GO:0002091 negative regulation of receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0002151 G-quadruplex RNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0006397 mRNA processing
GO:0006974 cellular response to DNA damage stimulus
GO:0007215 glutamate receptor signaling pathway
GO:0007417 central nervous system development
GO:0008017 microtubule binding
GO:0008089 anterograde axonal transport
GO:0008266 poly(U) RNA binding
GO:0008380 RNA splicing
GO:0010369 chromocenter
GO:0010494 cytoplasmic stress granule
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010955 negative regulation of protein processing
GO:0014069 postsynaptic density
GO:0015030 Cajal body
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019897 extrinsic component of plasma membrane
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030371 translation repressor activity
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031047 gene silencing by RNA
GO:0031369 translation initiation factor binding
GO:0032433 filopodium tip
GO:0033129 positive regulation of histone phosphorylation
GO:0033592 RNA strand annealing activity
GO:0034046 poly(G) binding
GO:0034644 cellular response to UV
GO:0035064 methylated histone binding
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035613 RNA stem-loop binding
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042734 presynaptic membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043488 regulation of mRNA stability
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044325 transmembrane transporter binding
GO:0044326 dendritic spine neck
GO:0044327 dendritic spine head
GO:0044830 modulation by host of viral RNA genome replication
GO:0045182 translation regulator activity
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0045665 negative regulation of neuron differentiation
GO:0045727 positive regulation of translation
GO:0045947 negative regulation of translational initiation
GO:0046928 regulation of neurotransmitter secretion
GO:0046982 protein heterodimerization activity
GO:0048027 mRNA 5'-UTR binding
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050806 positive regulation of synaptic transmission
GO:0051028 mRNA transport
GO:0051489 regulation of filopodium assembly
GO:0051491 positive regulation of filopodium assembly
GO:0060964 regulation of gene silencing by miRNA
GO:0060996 dendritic spine development
GO:0060998 regulation of dendritic spine development
GO:0060999 positive regulation of dendritic spine development
GO:0070840 dynein complex binding
GO:0071598 neuronal ribonucleoprotein granule
GO:0072711 cellular response to hydroxyurea
GO:0097386 glial cell projection
GO:0097444 spine apparatus
GO:0098586 cellular response to virus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098908 regulation of neuronal action potential
GO:0098978 glutamatergic synapse
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0099577 regulation of translation at presynapse, modulating synaptic transmission
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1900453 negative regulation of long-term synaptic depression
GO:1900454 positive regulation of long-term synaptic depression
GO:1901254 positive regulation of intracellular transport of viral material
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902373 negative regulation of mRNA catabolic process
GO:1902416 positive regulation of mRNA binding
GO:1902737 dendritic filopodium
GO:1904115 axon cytoplasm
GO:1905244 regulation of modification of synaptic structure
GO:1990124 messenger ribonucleoprotein complex
GO:1990635 proximal dendrite
GO:1990812 growth cone filopodium
GO:1990825 sequence-specific mRNA binding
GO:1990904 ribonucleoprotein complex
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000766 negative regulation of cytoplasmic translation
GO:2001022 positive regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Chromosome
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR004087 K Homology domainDomainDomain
IPR004088 K Homology domain, type 1DomainDomain
IPR008395 Agenet-like domainDomainDomain
IPR022034 Fragile X-related 1 protein, C-terminal coreDomainDomain
IPR032196 Fragile X-related mental retardation protein, C-terminal region 2DomainDomain
IPR036612 K Homology domain, type 1 superfamilyFamilyHomologous superfamily
IPR040148 Fragile X mental retardation syndrome-related proteinFamilyFamily
IPR040472 Synaptic functional regulator FMRP, KH0 domainDomainDomain
IPR041560 Fxr1, tudor domainDomainDomain

Diseases

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