Entity Details

Primary name LDLR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35951
EntryNameLDLR_MOUSE
FullNameLow-density lipoprotein receptor
TaxID10090
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesLdlr

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002020 protease binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007616 long-term memory
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010898 positive regulation of triglyceride catabolic process
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0034362 low-density lipoprotein particle
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0036477 somatodendritic compartment
GO:0042157 lipoprotein metabolic process
GO:0042159 lipoprotein catabolic process
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0048844 artery morphogenesis
GO:0050729 positive regulation of inflammatory response
GO:0051246 regulation of protein metabolic process
GO:0051248 negative regulation of protein metabolic process
GO:0055038 recycling endosome membrane
GO:0061771 response to caloric restriction
GO:0061889 negative regulation of astrocyte activation
GO:0070508 cholesterol import
GO:0071398 cellular response to fatty acid
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0090181 regulation of cholesterol metabolic process
GO:0097242 amyloid-beta clearance
GO:0097443 sorting endosome
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1903979 negative regulation of microglial cell activation
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:1905907 negative regulation of amyloid fibril formation
GO:1990666 PCSK9-LDLR complex

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome
Golgi apparatus
Late endosome
Lysosome
Membrane

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LDLR_MOUSEDAB1_MOUSEBioGRID, IntAct10380922 10827173 details
LDLR_MOUSEVGFR1_MOUSEBioGRID, MINT17962812 details