Entity Details

Primary name VGFR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP35969
EntryNameVGFR1_MOUSE
FullNameVascular endothelial growth factor receptor 1
TaxID10090
Evidenceevidence at protein level
Length1333
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFlt1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001666 response to hypoxia
GO:0002040 sprouting angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002548 monocyte chemotaxis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030335 positive regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
GO:0036332 placental growth factor-activated receptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048598 embryonic morphogenesis
GO:1901534 positive regulation of hematopoietic progenitor cell differentiation
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1990384 hyaloid vascular plexus regression

Subcellular Location

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Subcellular Location
Cell membrane
Endosome

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041348 VEGFR-2, Transmembrane domainDomainDomain

Diseases

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