Entity Details

Primary name NCPR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP37040
EntryNameNCPR_MOUSE
FullNameNADPH--cytochrome P450 reductase
TaxID10090
Evidenceevidence at protein level
Length678
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPor

GO terms

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GOName
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0007584 response to nutrient
GO:0008941 nitric oxide dioxygenase activity
GO:0009055 electron transfer activity
GO:0009437 carnitine metabolic process
GO:0009725 response to hormone
GO:0009812 flavonoid metabolic process
GO:0010181 FMN binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016787 hydrolase activity
GO:0018393 internal peptidyl-lysine acetylation
GO:0019395 fatty acid oxidation
GO:0019899 enzyme binding
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032770 positive regulation of monooxygenase activity
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043602 nitrate catabolic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045880 positive regulation of smoothened signaling pathway
GO:0046210 nitric oxide catabolic process
GO:0047726 iron-cytochrome-c reductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0060192 negative regulation of lipase activity
GO:0070988 demethylation
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0090031 positive regulation of steroid hormone biosynthetic process
GO:0090181 regulation of cholesterol metabolic process
GO:0090346 cellular organofluorine metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR023208 NADPH-cytochrome P450 reductaseFamilyFamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
NCPR_MOUSEPA24A_MOUSEIntAct15102471 details
NCPR_MOUSEFANCC_MOUSEBioGRID9787138 details