Entity Details

Primary name PPARG_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP37238
EntryNamePPARG_MOUSE
FullNamePeroxisome proliferator-activated receptor gamma
TaxID10090
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesPparg

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001818 negative regulation of cytokine production
GO:0001890 placenta development
GO:0002021 response to dietary excess
GO:0002024 diet induced thermogenesis
GO:0002674 negative regulation of acute inflammatory response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006631 fatty acid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008217 regulation of blood pressure
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009416 response to light stimulus
GO:0009755 hormone-mediated signaling pathway
GO:0010468 regulation of gene expression
GO:0010742 macrophage derived foam cell differentiation
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0015909 long-chain fatty acid transport
GO:0016525 negative regulation of angiogenesis
GO:0019216 regulation of lipid metabolic process
GO:0019395 fatty acid oxidation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030154 cell differentiation
GO:0030224 monocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030514 negative regulation of BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0032094 response to food
GO:0032869 cellular response to insulin stimulus
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033993 response to lipid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042277 peptide binding
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0042953 lipoprotein transport
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043388 positive regulation of DNA binding
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043621 protein self-association
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0046965 retinoid X receptor binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050544 arachidonic acid binding
GO:0050692 DNA binding domain binding
GO:0050693 LBD domain binding
GO:0050699 WW domain binding
GO:0050728 negative regulation of inflammatory response
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051393 alpha-actinin binding
GO:0051974 negative regulation of telomerase activity
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060965 negative regulation of gene silencing by miRNA
GO:0070888 E-box binding
GO:0071285 cellular response to lithium ion
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0090278 negative regulation of peptide hormone secretion
GO:0090575 RNA polymerase II transcription regulator complex
GO:0150079 negative regulation of neuroinflammatory response
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903979 negative regulation of microglial cell activation
GO:1904179 positive regulation of adipose tissue development
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1905599 positive regulation of low-density lipoprotein receptor activity
GO:1990841 promoter-specific chromatin binding
GO:2000230 negative regulation of pancreatic stellate cell proliferation
GO:2000272 negative regulation of signaling receptor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003074 Peroxisome proliferator-activated receptorFamilyFamily
IPR003077 Peroxisome proliferator-activated receptor gammaFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminalDomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
PPARG_MOUSESIR1_HUMANIntAct22863012 details
PPARG_MOUSEMED1_HUMANBioGRID, UniProt12037571 9653119 details
PPARG_MOUSERXRA_HUMANBioGRID10517671 details
PPARG_MOUSEMEN1_MOUSEBioGRID19596783 details
PPARG_MOUSENCOR2_HUMANBioGRID16219912 details
PPARG_MOUSETGFI1_HUMANBioGRID15687259 details
PPARG_MOUSENF2L2_HUMANBioGRID10930400 details
PPARG_MOUSESP1_MOUSEBioGRID11777901 details
PPARG_MOUSENCOA2_MOUSEBioGRID22664386 details
PPARG_MOUSEPIAS2_MOUSEBioGRID15123625 details
PPARG_MOUSENCOR1_HUMANBioGRID11903058 details
PPARG_MOUSERXRA_MOUSEBioGRID22573555 details
PPARG_MOUSEFBX9_MOUSEBioGRID27197753 details
PPARG_MOUSESIR1_MOUSEBioGRID, IntAct, UniProt15175761 22863012 details
PPARG_MOUSEPRD16_MOUSEIntAct22863012 details
PPARG_MOUSENOCT_MOUSEDIP20498072 details
PPARG_MOUSEFOXP3_MOUSEDIP22722857 details
PPARG_MOUSEIRF6_MOUSEIntAct28526834 details
PPARG_MOUSETACC1_HUMANIntAct20078863 details
PPARG_MOUSEGA45A_HUMANBioGRID10872826 details
PPARG_MOUSEHDAC1_MOUSEBioGRID16431920 details
PPARG_MOUSESIAH2_MOUSEBioGRID22294748 details
PPARG_MOUSEHS90A_HUMANBioGRID12962497 details
PPARG_MOUSEBCL6_HUMANBioGRID12970571 details
PPARG_MOUSETF65_MOUSEBioGRID23250430 details
PPARG_MOUSECAV1_MOUSEBioGRID15164767 details
PPARG_MOUSETGIF1_MOUSEBioGRID16428452 details
PPARG_MOUSEMED14_MOUSEBioGRID20194623 details
PPARG_MOUSEPRGC1_MOUSEBioGRID15687259 25368164 details
PPARG_MOUSETGFI1_MOUSEBioGRID15687259 details
PPARG_MOUSEUBP7_MOUSEBioGRID24072712 details
PPARG_MOUSEVIME_MOUSEBioGRID23297177 details
PPARG_MOUSEDESM_MOUSEBioGRID23297177 details
PPARG_MOUSEPPM1B_MOUSEBioGRID23320500 details
PPARG_MOUSEABL1_MOUSEBioGRID25368164 details
PPARG_MOUSESNX19_HUMANBioGRID27197753 details
PPARG_MOUSEPLD2_HUMANBioGRID27197753 details
PPARG_MOUSETRADD_HUMANBioGRID27197753 details
PPARG_MOUSEADA22_HUMANBioGRID27197753 details
PPARG_MOUSEITPA_HUMANBioGRID27197753 details
PPARG_MOUSEFBX9_HUMANBioGRID27197753 details
PPARG_MOUSEPDYN_HUMANBioGRID27197753 details
PPARG_MOUSETNF11_HUMANBioGRID27197753 details
PPARG_MOUSEACTB_HUMANBioGRID27197753 details
PPARG_MOUSEM3K7_HUMANBioGRID27197753 details
PPARG_MOUSEZC3H3_HUMANBioGRID27197753 details
PPARG_MOUSEACTBL_HUMANBioGRID27197753 details
PPARG_MOUSEACTG_HUMANBioGRID27197753 details
PPARG_MOUSEZRAB3_HUMANBioGRID27197753 details
PPARG_MOUSEPK1L3_HUMANBioGRID27197753 details
PPARG_MOUSEDUOX1_HUMANBioGRID27197753 details
PPARG_MOUSERTCB_HUMANBioGRID27197753 details
PPARG_MOUSETARA_HUMANBioGRID27197753 details
PPARG_MOUSELAMC2_HUMANBioGRID27197753 details
PPARG_MOUSEMLH1_HUMANBioGRID27197753 details
PPARG_MOUSE5HT3D_HUMANBioGRID27197753 details
PPARG_MOUSEABCA5_HUMANBioGRID27197753 details
PPARG_MOUSEPPARG_HUMANBioGRID27197753 details
PPARG_MOUSEAP3D1_HUMANBioGRID27197753 details
PPARG_MOUSEHECD2_HUMANBioGRID27197753 details
PPARG_MOUSETRPV6_HUMANBioGRID27197753 details
PPARG_MOUSEDCST1_HUMANBioGRID27197753 details
PPARG_MOUSETOPB1_HUMANBioGRID27197753 details
PPARG_MOUSEITA8_HUMANBioGRID27197753 details
PPARG_MOUSEAIFM3_HUMANBioGRID27197753 details
PPARG_MOUSETITIN_HUMANBioGRID27197753 details
PPARG_MOUSEZN404_HUMANBioGRID27197753 details
PPARG_MOUSEKI18B_HUMANBioGRID27197753 details
PPARG_MOUSETIGD1_HUMANBioGRID27197753 details
PPARG_MOUSEGARL3_HUMANBioGRID27197753 details
PPARG_MOUSECOPRS_HUMANBioGRID27197753 details
PPARG_MOUSEHYAS1_HUMANBioGRID27197753 details
PPARG_MOUSESCAPE_HUMANBioGRID27197753 details
PPARG_MOUSEITA9_HUMANBioGRID27197753 details
PPARG_MOUSECHD1_HUMANBioGRID27197753 details
PPARG_MOUSENEDD4_MOUSEBioGRID27917940 details
PPARG_MOUSEWWTR1_MOUSEBioGRID16099986 details
PPARG_MOUSESMUF1_MOUSEBioGRID30566427 details