Entity Details

Primary name HSF1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP38532
EntryNameHSF1_MOUSE
FullNameHeat shock factor protein 1
TaxID10090
Evidenceevidence at protein level
Length525
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesHsf1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000776 kinetochore
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0006952 defense response
GO:0007143 female meiotic nuclear division
GO:0007283 spermatogenesis
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009299 mRNA transcription
GO:0009408 response to heat
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031490 chromatin DNA binding
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034620 cellular response to unfolded protein
GO:0034622 cellular protein-containing complex assembly
GO:0040018 positive regulation of multicellular organism growth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0045120 pronucleus
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051028 mRNA transport
GO:0051879 Hsp90 protein binding
GO:0060136 embryonic process involved in female pregnancy
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0061770 translation elongation factor binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071230 cellular response to amino acid stimulus
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0071392 cellular response to estradiol stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071478 cellular response to radiation
GO:0071480 cellular response to gamma radiation
GO:0072738 cellular response to diamide
GO:0090084 negative regulation of inclusion body assembly
GO:0090261 positive regulation of inclusion body assembly
GO:0097165 nuclear stress granule
GO:0097431 mitotic spindle pole
GO:0097677 STAT family protein binding
GO:0098847 sequence-specific single stranded DNA binding
GO:0101031 chaperone complex
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900034 regulation of cellular response to heat
GO:1900365 positive regulation of mRNA polyadenylation
GO:1901215 negative regulation of neuron death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903936 cellular response to sodium arsenite
GO:1904385 cellular response to angiotensin
GO:1904528 positive regulation of microtubule binding
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:1990904 ribonucleoprotein complex
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000232 Heat shock factor (HSF)-type, DNA-bindingDomainDomain
IPR010542 Vertebrate heat shock transcription factor, C-terminal domainDomainDomain
IPR027725 Heat shock transcription factor familyFamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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