Entity Details

Primary name ZO1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP39447
EntryNameZO1_MOUSE
FullNameTight junction protein ZO-1
TaxID10090
Evidenceevidence at protein level
Length1745
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesTjp1

GO terms

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GOName
GO:0001825 blastocyst formation
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005921 gap junction
GO:0005923 bicellular tight junction
GO:0007605 sensory perception of sound
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0019904 protein domain specific binding
GO:0030054 cell junction
GO:0030335 positive regulation of cell migration
GO:0031032 actomyosin structure organization
GO:0031674 I band
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034334 adherens junction maintenance
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0045216 cell-cell junction organization
GO:0045471 response to ethanol
GO:0046581 intercellular canaliculus
GO:0050839 cell adhesion molecule binding
GO:0051493 regulation of cytoskeleton organization
GO:0051497 negative regulation of stress fiber assembly
GO:0070160 tight junction
GO:0071000 response to magnetism
GO:0071253 connexin binding
GO:0071333 cellular response to glucose stimulus
GO:0071896 protein localization to adherens junction
GO:0090557 establishment of endothelial intestinal barrier
GO:0098609 cell-cell adhesion
GO:0150105 protein localization to cell-cell junction
GO:1901888 regulation of cell junction assembly
GO:1902396 protein localization to bicellular tight junction
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905605 positive regulation of blood-brain barrier permeability
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000250 negative regulation of actin cytoskeleton reorganization
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000906 ZU5 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR005417 Tight junction protein ZOFamilyFamily
IPR005418 Tight junction protein ZO-1FamilyFamily
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035597 ZO-1, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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