Entity Details

Primary name FYN_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP39688
EntryNameFYN_MOUSE
FullNameTyrosine-protein kinase Fyn
TaxID10090
Evidenceevidence at protein level
Length537
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesFyn

GO terms

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GOName
GO:0000304 response to singlet oxygen
GO:0001664 G protein-coupled receptor binding
GO:0001764 neuron migration
GO:0002250 adaptive immune response
GO:0003015 heart process
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008360 regulation of cell shape
GO:0010629 negative regulation of gene expression
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0015631 tubulin binding
GO:0016004 phospholipase activator activity
GO:0016020 membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0030425 dendrite
GO:0030900 forebrain development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031397 negative regulation of protein ubiquitination
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0035556 intracellular signal transduction
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042542 response to hydrogen peroxide
GO:0042552 myelination
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043274 phospholipase binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044297 cell body
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048813 dendrite morphogenesis
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050804 modulation of chemical synaptic transmission
GO:0050852 T cell receptor signaling pathway
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051428 peptide hormone receptor binding
GO:0070851 growth factor receptor binding
GO:0071375 cellular response to peptide hormone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071944 cell periphery
GO:0090314 positive regulation of protein targeting to membrane
GO:0097038 perinuclear endoplasmic reticulum
GO:0097386 glial cell projection
GO:0097718 disordered domain specific binding
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1900182 positive regulation of protein localization to nucleus
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905232 cellular response to L-glutamate
GO:1905430 cellular response to glycine
GO:1905664 regulation of calcium ion import across plasma membrane
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035750 Fyn/Yrk, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
FYN_MOUSESLAF1_MOUSEMINT11477403 12545173 16847311 details
FYN_MOUSEKHDR1_MOUSEBioGRID, IntAct, UniProt10077576 10844001 15102471 details
FYN_MOUSEBCAR1_MOUSEBioGRID, IntAct15102471 17875741 details
FYN_MOUSERAVR1_MOUSEIntAct15102471 details
FYN_MOUSEDYLT1_MOUSEIntAct15102471 details
FYN_MOUSEFAK1_MOUSEBioGRID, IntAct15102471 17875741 details
FYN_MOUSEUCK2_MOUSEIntAct15102471 details
FYN_MOUSESPHK2_MOUSEIntAct16316995 details
FYN_MOUSECBL_HUMANMINT9890970 details
FYN_MOUSEFZD2_HUMANIntAct25417160 details
FYN_MOUSEENOA_MOUSEBioGRID18854310 details
FYN_MOUSEPTPRF_MOUSEBioGRID18854310 details
FYN_MOUSEENAH_MOUSEBioGRID8861907 details
FYN_MOUSEFMN1_MOUSEBioGRID8605874 details
FYN_MOUSEWASP_MOUSEBioGRID14707117 details
FYN_MOUSECD36_MOUSEBioGRID25157091 details
FYN_MOUSEDAB1_MOUSEBioGRID16529723 details
FYN_MOUSESH21A_MOUSEMINT12545173 16847311 details
FYN_MOUSECLNK_MOUSEMINT12681493 details
FYN_MOUSEFYB1_MOUSEMINT12681493 details
FYN_MOUSESKAP2_MOUSEMINT12681493 details
FYN_MOUSEHCLS1_MOUSEIntAct10713104 details
FYN_MOUSEMED28_HUMANIntAct16899217 details
FYN_MOUSEMED28_MOUSEIntAct16899217 details
FYN_MOUSERHG33_MOUSEIntAct16777849 details
FYN_MOUSEPLCG2_MOUSEMINT8395016 details
FYN_MOUSEP85A_MOUSEBioGRID, MINT8395016 9115297 details
FYN_MOUSECBL_MOUSEBioGRID, IntAct, MINT19734451 27474268 8551236 8635998 9210408 9890970 details
FYN_MOUSEPTPRT_HUMANMINT19816407 details
FYN_MOUSECLIC5_HUMANMINT10930415 details
FYN_MOUSEADDB_MOUSEMINT16765915 details
FYN_MOUSEPGFRB_MOUSEMINT7730365 details
FYN_MOUSECSF1R_HUMANMINT7730365 details
FYN_MOUSECTLA4_MOUSEMINT9712716 details
FYN_MOUSETAU_HUMANMINT21692989 details
FYN_MOUSEPTPRA_MOUSEMINT18948260 9535845 details
FYN_MOUSEPTPRA_HUMANMINT9535845 details
FYN_MOUSEPLXA2_HUMANmbinfo12372285 details
FYN_MOUSECDK5_MOUSEmbinfo12372285 details
FYN_MOUSETMM47_MOUSEUniProt21881001 details
FYN_MOUSEKHDR2_MOUSEUniProt10077576 details
FYN_MOUSECSF1R_MOUSEBioGRID15297464 details
FYN_MOUSEDIAP1_MOUSEBioGRID18194650 details
FYN_MOUSESH21C_MOUSEBioGRID16425036 details
FYN_MOUSEVGFR2_MOUSEBioGRID16966330 details
FYN_MOUSENCK1_MOUSEBioGRID16966330 details
FYN_MOUSEPTN5_MOUSEBioGRID27457929 details