Entity Details

Primary name CDN1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP39689
EntryNameCDN1A_MOUSE
FullNameCyclin-dependent kinase inhibitor 1
TaxID10090
Evidenceevidence at protein level
Length159
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesCdkn1a

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0004860 protein kinase inhibitor activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006606 protein import into nucleus
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0007507 heart development
GO:0008285 negative regulation of cell population proliferation
GO:0009411 response to UV
GO:0009636 response to toxic substance
GO:0010165 response to X-ray
GO:0010243 response to organonitrogen compound
GO:0010629 negative regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0016604 nuclear body
GO:0019901 protein kinase binding
GO:0019912 cyclin-dependent protein kinase activating kinase activity
GO:0030308 negative regulation of cell growth
GO:0030332 cyclin binding
GO:0030890 positive regulation of B cell proliferation
GO:0031100 animal organ regeneration
GO:0031625 ubiquitin protein ligase binding
GO:0031668 cellular response to extracellular stimulus
GO:0032091 negative regulation of protein binding
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034605 cellular response to heat
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0044877 protein-containing complex binding
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860 positive regulation of protein kinase activity
GO:0046685 response to arsenic-containing substance
GO:0046872 metal ion binding
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0051412 response to corticosterone
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060574 intestinal epithelial cell maturation
GO:0070557 PCNA-p21 complex
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0071493 cellular response to UV-B
GO:0090398 cellular senescence
GO:0140311 protein sequestering activity
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1904030 negative regulation of cyclin-dependent protein kinase activity
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905179 negative regulation of cardiac muscle tissue regeneration
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000278 regulation of DNA biosynthetic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003175 Cyclin-dependent kinase inhibitor domainDomainDomain
IPR029841 Cyclin-dependent kinase inhibitor 1FamilyFamily

Diseases

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