Entity Details

Primary name NLRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96P20
EntryNameNLRP3_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 3
TaxID9606
Evidenceevidence at protein level
Length1036
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesNLRP3

GO terms

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GOName
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0014070 response to organic cyclic compound
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042834 peptidoglycan binding
GO:0000139 Golgi membrane
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0005737 cytoplasm
GO:0006952 defense response
GO:0007165 signal transduction
GO:0016579 protein deubiquitination
GO:0032753 positive regulation of interleukin-4 production
GO:0043565 sequence-specific DNA binding
GO:0045471 response to ethanol
GO:0050728 negative regulation of inflammatory response
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0006954 inflammatory response
GO:0009595 detection of biotic stimulus
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071222 cellular response to lipopolysaccharide
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:0002674 negative regulation of acute inflammatory response
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0072559 NLRP3 inflammasome complex

Subcellular Location

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Subcellular Location
Golgi apparatus membrane
Nucleus
Secreted
Cytoplasm
Endoplasmic reticulum
Inflammasome

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029495 NACHT-associated domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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