Entity Details

Primary name TNFL6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP41047
EntryNameTNFL6_MOUSE
FullNameTumor necrosis factor ligand superfamily member 6
TaxID10090
Evidenceevidence at protein level
Length279
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesFasl

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005123 death receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0008284 positive regulation of cell population proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016525 negative regulation of angiogenesis
GO:0030644 cellular chloride ion homeostasis
GO:0031410 cytoplasmic vesicle
GO:0032496 response to lipopolysaccharide
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043202 lysosomal lumen
GO:0043525 positive regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666 retinal cell programmed cell death
GO:0048388 endosomal lumen acidification
GO:0048471 perinuclear region of cytoplasm
GO:0060205 cytoplasmic vesicle lumen
GO:0070062 extracellular exosome
GO:0070231 T cell apoptotic process
GO:0070266 necroptotic process
GO:0070848 response to growth factor
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum
GO:1905782 positive regulation of phosphatidylserine exposure on apoptotic cell surface
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle lumen
Lysosome lumen
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR006053 Tumour necrosis factorFamilyFamily
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR028326 Tumor necrosis factor ligand superfamily member 6FamilyFamily

Diseases

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Interactions

4 interactions