Entity Details

Primary name CRBN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96SW2
EntryNameCRBN_HUMAN
FullNameProtein cereblon
TaxID9606
Evidenceevidence at protein level
Length442
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesCRBN

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR003111 Lon, substrate-binding domainDomainDomain
IPR004910 Yippee/Mis18/CereblonDomainDomain
IPR015947 PUA-like superfamilyFamilyHomologous superfamily
IPR034750 CULT domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00480 LenalidomideDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB08910 PomalidomideDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink