Entity Details

Primary name BARD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99728
EntryNameBARD1_HUMAN
FullNameBRCA1-associated RING domain protein 1
TaxID9606
Evidenceevidence at protein level
Length777
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesBARD1

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000729 DNA double-strand break processing
GO:0001894 tissue homeostasis
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006260 DNA replication
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006974 cellular response to DNA damage stimulus
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016607 nuclear speck
GO:0019900 kinase binding
GO:0031436 BRCA1-BARD1 complex
GO:0031441 negative regulation of mRNA 3'-end processing
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042325 regulation of phosphorylation
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0046826 negative regulation of protein export from nucleus
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0070531 BRCA1-A complex
GO:0085020 protein K6-linked ubiquitination
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR039503 BARD1, Zinc finger, RING-typeDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
BARD1_HUMANHAP1_MOUSEIntAct15383276 details