Entity Details

Primary name STAT1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP42225
EntryNameSTAT1_MOUSE
FullNameSignal transducer and activator of transcription 1
TaxID10090
Evidenceevidence at protein level
Length749
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002230 positive regulation of defense response to virus by host
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 defense response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0010742 macrophage derived foam cell differentiation
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031730 CCR5 chemokine receptor binding
GO:0032496 response to lipopolysaccharide
GO:0032727 positive regulation of interferon-alpha production
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0034240 negative regulation of macrophage fusion
GO:0034340 response to type I interferon
GO:0035035 histone acetyltransferase binding
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
GO:0042127 regulation of cell population proliferation
GO:0042393 histone binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043434 response to peptide hormone
GO:0043565 sequence-specific DNA binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0051721 protein phosphatase 2A binding
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0061326 renal tubule development
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071407 cellular response to organic cyclic compound
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminalDomainDomain
IPR035859 STAT1, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR038295 STAT1, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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