Entity Details

Primary name M3K3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99759
EntryNameM3K3_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 3
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP3K3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900745 positive regulation of p38MAPK cascade
GO:2000773 negative regulation of cellular senescence

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR034879 Mitogen-activated protein kinase kinase kinase 2/3, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
M3K3_HUMAN1433E_MOUSEMINT9452471 details