Entity Details

Primary name STAT3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP42227
EntryNameSTAT3_MOUSE
FullNameSignal transducer and activator of transcription 3
TaxID10090
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesStat3

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006606 protein import into nucleus
GO:0006952 defense response
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0014069 postsynaptic density
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019953 sexual reproduction
GO:0030335 positive regulation of cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0031490 chromatin DNA binding
GO:0031730 CCR5 chemokine receptor binding
GO:0032355 response to estradiol
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032870 cellular response to hormone stimulus
GO:0033210 leptin-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035259 glucocorticoid receptor binding
GO:0040014 regulation of multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0042789 mRNA transcription by RNA polymerase II
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043434 response to peptide hormone
GO:0043565 sequence-specific DNA binding
GO:0044320 cellular response to leptin stimulus
GO:0044321 response to leptin
GO:0045471 response to ethanol
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046983 protein dimerization activity
GO:0048708 astrocyte differentiation
GO:0050804 modulation of chemical synaptic transmission
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060019 radial glial cell differentiation
GO:0060259 regulation of feeding behavior
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070878 primary miRNA binding
GO:0071345 cellular response to cytokine stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0072538 T-helper 17 type immune response
GO:0072540 T-helper 17 cell lineage commitment
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097009 energy homeostasis
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904685 positive regulation of metalloendopeptidase activity
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:2000635 negative regulation of primary miRNA processing
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000737 negative regulation of stem cell differentiation
GO:2001171 positive regulation of ATP biosynthetic process
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR035855 STAT3, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
STAT3_MOUSEHAX1_MOUSEIntAct15102471 details
STAT3_MOUSEHSPB1_MOUSEIntAct15102471 details
STAT3_MOUSEK2C1_MOUSEIntAct15102471 details
STAT3_MOUSEMLF2_MOUSEIntAct15102471 details
STAT3_MOUSEHUWE1_MOUSEIntAct15102471 details
STAT3_MOUSEBANK1_MOUSEIntAct15102471 details
STAT3_MOUSECRYAB_MOUSEIntAct, MINT15102471 27724964 details
STAT3_MOUSECP110_MOUSEIntAct15102471 details
STAT3_MOUSEIL6RB_HUMANIntAct, MINT10982829 8662591 details
STAT3_MOUSESRC_HUMANIntAct10982829 details
STAT3_MOUSEINGR1_HUMANMINT8662591 details
STAT3_MOUSESTAT3_HUMANMINT8662591 details
STAT3_MOUSESTAT3_MOUSEBioGRID, DIP, MINT11579100 17463090 20211142 23434585 details
STAT3_MOUSEDAPK3_MOUSEUniProt16219639 details
STAT3_MOUSEKSYK_MOUSEDIP20133729 details
STAT3_MOUSEJUN_MOUSEBioGRID20211142 details
STAT3_MOUSEJAK2_MOUSEBioGRID15143188 21102457 22402124 details
STAT3_MOUSEM3K7_HUMANIntAct15764709 details
STAT3_MOUSEG45IP_HUMANMINT18200042 details
STAT3_MOUSEPRGR_MOUSEBioGRID, IntAct20876300 21184768 details
STAT3_MOUSEERBB2_MOUSEIntAct20876300 details
STAT3_MOUSEECHM_HUMANMINT23416296 details
STAT3_MOUSECDK6_MOUSEIntAct23948297 details
STAT3_MOUSESH2B1_HUMANMINT24396070 details
STAT3_MOUSENDUAD_MOUSEBioGRID, IntAct20682646 32325033 details
STAT3_MOUSEFOXP3_MOUSEBioGRID, IntAct19797626 22922362 25126783 25642823 25993445 details
STAT3_MOUSETBXT_MOUSEDIP16801560 details
STAT3_MOUSEEFNB1_MOUSEDIP17954917 details
STAT3_MOUSEEP300_HUMANBioGRID10464260 details
STAT3_MOUSEPCBP1_MOUSEBioGRID17383969 details
STAT3_MOUSEARI1B_MOUSEBioGRID17255939 details
STAT3_MOUSETMF1_MOUSEBioGRID15467733 details
STAT3_MOUSEJAK3_MOUSEBioGRID22402124 details
STAT3_MOUSECSF1R_MOUSEBioGRID10330148 details
STAT3_MOUSEIRAK1_MOUSEBioGRID15465816 details
STAT3_MOUSEPIAS3_HUMANBioGRID9388184 details
STAT3_MOUSEFER_MOUSEBioGRID12738762 details
STAT3_MOUSEHES1_MOUSEBioGRID15156153 details
STAT3_MOUSEZN467_MOUSEBioGRID12426389 details
STAT3_MOUSECYLD_MOUSEBioGRID23825949 details
STAT3_MOUSEIRF4_MOUSEBioGRID20064451 details
STAT3_MOUSECRTC2_HUMANBioGRID27362806 details
STAT3_MOUSECRTC3_HUMANBioGRID27362806 details
STAT3_MOUSEOCAD1_MOUSEBioGRID23972987 details
STAT3_MOUSEVGFR2_MOUSEBioGRID25881542 details