Entity Details

Primary name EPAS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99814
EntryNameEPAS1_HUMAN
FullNameEndothelial PAS domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length870
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesEPAS1

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0001974 blood vessel remodeling
GO:0002027 regulation of heart rate
GO:0003677 DNA binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0008134 transcription factor binding
GO:0016567 protein ubiquitination
GO:0016607 nuclear speck
GO:0030218 erythrocyte differentiation
GO:0030324 lung development
GO:0035019 somatic stem cell population maintenance
GO:0035035 histone acetyltransferase binding
GO:0042415 norepinephrine metabolic process
GO:0043129 surfactant homeostasis
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043687 post-translational protein modification
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048469 cell maturation
GO:0048625 myoblast fate commitment
GO:0055072 iron ion homeostasis
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000434 regulation of protein neddylation

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR014887 HIF-1 alpha, transactivation domain, C-terminalDomainDomain
IPR021537 Hypoxia-inducible factor, alpha subunitFamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15463 PT2977Drugbanksmall molecule

Interactions

3 interactions