Entity Details

Primary name STA5B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP42232
EntryNameSTA5B_MOUSE
FullNameSignal transducer and activator of transcription 5B
TaxID10090
Evidenceevidence at protein level
Length786
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesStat5b

GO terms

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GOName
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001553 luteinization
GO:0001779 natural killer cell differentiation
GO:0001889 liver development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006952 defense response
GO:0006953 acute-phase response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032743 positive regulation of interleukin-2 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032870 cellular response to hormone stimulus
GO:0033077 T cell differentiation in thymus
GO:0035259 glucocorticoid receptor binding
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042127 regulation of cell population proliferation
GO:0042448 progesterone metabolic process
GO:0042802 identical protein binding
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0043565 sequence-specific DNA binding
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0046983 protein dimerization activity
GO:0048541 Peyer's patch development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051272 positive regulation of cellular component movement
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097531 mast cell migration

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR035858 STAT5a/5bFamilyFamily
IPR035886 STAT5b, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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