Entity Details

Primary name HD_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP42859
EntryNameHD_MOUSE
FullNameHuntingtin
TaxID10090
Evidenceevidence at protein level
Length3119
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000050 urea cycle
GO:0000052 citrulline metabolic process
GO:0000132 establishment of mitotic spindle orientation
GO:0002039 p53 binding
GO:0005102 signaling receptor binding
GO:0005522 profilin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005814 centriole
GO:0005829 cytosol
GO:0006839 mitochondrial transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0007005 mitochondrion organization
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007212 dopamine receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007369 gastrulation
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0007569 cell aging
GO:0007611 learning or memory
GO:0007612 learning
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0008088 axo-dendritic transport
GO:0008134 transcription factor binding
GO:0008306 associative learning
GO:0008340 determination of adult lifespan
GO:0008542 visual learning
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0010468 regulation of gene expression
GO:0014069 postsynaptic density
GO:0016197 endosomal transport
GO:0016234 inclusion body
GO:0019244 lactate biosynthetic process from pyruvate
GO:0019805 quinolinate biosynthetic process
GO:0019900 kinase binding
GO:0021756 striatum development
GO:0021988 olfactory lobe development
GO:0021990 neural plate formation
GO:0022008 neurogenesis
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030136 clathrin-coated vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031072 heat shock protein binding
GO:0031410 cytoplasmic vesicle
GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0034452 dynactin binding
GO:0034504 protein localization to nucleus
GO:0035176 social behavior
GO:0042297 vocal learning
GO:0042445 hormone metabolic process
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044325 transmembrane transporter binding
GO:0045505 dynein intermediate chain binding
GO:0045724 positive regulation of cilium assembly
GO:0047496 vesicle transport along microtubule
GO:0048167 regulation of synaptic plasticity
GO:0048341 paraxial mesoderm formation
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0048666 neuron development
GO:0050809 diazepam binding
GO:0051028 mRNA transport
GO:0051592 response to calcium ion
GO:0055072 iron ion homeostasis
GO:0071539 protein localization to centrosome
GO:0071598 neuronal ribonucleoprotein granule
GO:0097060 synaptic membrane
GO:0098978 glutamatergic synapse
GO:0099111 microtubule-based transport
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0099527 postsynapse to nucleus signaling pathway
GO:1900180 regulation of protein localization to nucleus
GO:1902857 positive regulation of non-motile cilium assembly
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1904504 positive regulation of lipophagy
GO:1904580 regulation of intracellular mRNA localization
GO:1905289 regulation of CAMKK-AMPK signaling cascade
GO:1905337 positive regulation of aggrephagy
GO:1905505 positive regulation of motile cilium assembly
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000479 regulation of cAMP-dependent protein kinase activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Nucleus

Domains

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DomainNameCategoryType
IPR000091 HuntingtinFamilyFamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR024613 Huntingtin, middle-repeatRepeatRepeat
IPR028426 Huntingtin familyFamilyFamily

Diseases

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