Entity Details

Primary name HHEX_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP43120
EntryNameHHEX_MOUSE
FullNameHematopoietically-expressed homeobox protein Hhex
TaxID10090
Evidenceevidence at protein level
Length271
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHhex

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0002009 morphogenesis of an epithelium
GO:0002573 myeloid leukocyte differentiation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006406 mRNA export from nucleus
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007492 endoderm development
GO:0008134 transcription factor binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0008301 DNA binding, bending
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0016055 Wnt signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0022027 interkinetic nuclear migration
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030183 B cell differentiation
GO:0030878 thyroid gland development
GO:0030900 forebrain development
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 pancreas development
GO:0032993 protein-DNA complex
GO:0034504 protein localization to nucleus
GO:0035050 embryonic heart tube development
GO:0035264 multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048568 embryonic organ development
GO:0048729 tissue morphogenesis
GO:0048853 forebrain morphogenesis
GO:0060431 primary lung bud formation
GO:0061009 common bile duct development
GO:0061010 gall bladder development
GO:0061011 hepatic duct development
GO:0061017 hepatoblast differentiation
GO:0070365 hepatocyte differentiation
GO:0070663 regulation of leukocyte proliferation
GO:0071103 DNA conformation change
GO:0071837 HMG box domain binding
GO:0090009 primitive streak formation
GO:0090263 positive regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
HHEX_MOUSESP7_MOUSEBioGRID, IntAct20211142 details
HHEX_MOUSETF2AY_MOUSEBioGRID, IntAct20211142 details
HHEX_MOUSEJUN_MOUSEBioGRID11551904 details
HHEX_MOUSEFOS_MOUSEBioGRID11551904 details